The biotransformation process, which is also referred to as the metabolic detoxification system, is the key biochemical process in a metabolic detoxification that is responsible for the elimination of toxins from the body. There are three distinct pathways that make up this system. For optimal function, the detoxification system is highly dependent on adequate nutrient support. Any detoxification program following Detox to Rehab, must provide the biotransformation system with nutritional support. Maintaining a sufficient energy supply is essential because detoxification is an energy-dependent process. Fasting or poor nourishing help during a detoxification program might have numerous unfavourable wellbeing impacts, including the following –
Fasting During Detoxification and Its Effects
- The majority of toxins are lipid-soluble molecules, which results in decreased levels of Phase II co-factors and up-regulation of detox
- Phase I enzyme activities, as well as an increase in oxidative stress and mood and sleep disturbances.
- Lipid-soluble molecules are easy for the body to excrete and can easily cross cell membranes, affecting cellular functions.
- Adipose tissue and the CNS are the primary storage locations for these lipid-soluble toxins.
- Additionally, the body has a complex, integrated system for converting lipid-soluble toxins into water-soluble molecules that can then be excreted through the renal or biliary systems.
- This system, which includes Phase I and Phase II metabolizing enzymes as well as Phase III protein transporters, is referred to as the detoxification system or biotransformation system.
Detoxification Transforming the Lipid Toxins
By binding the toxin to another molecule, such as an amino acid, methyl group, or glutathione, the detoxification system transforms lipid-soluble toxins into water-soluble molecules. However, the majority of toxins lack a reactive site that makes it possible for them to bind to a conjugation molecule. Stage I chemicals make a receptive site on the poison compound that empowers formation.
Phase I of the Detoxification Process
Transport for optimal function, the detoxification system is heavily dependent on adequate nutrient support. Any detoxification program must provide the biotransformation system with nutritional support. Bioactivation is the first phase. Stage I responses are catalysed by various catalysts, principally from the cytochrome P450 (CYP450) superfamily of compounds. To add a reactive group (hydroxyl, carboxyl, or amino) to a toxin, CYP450 enzymes carry out a variety of chemical reactions (oxidation, reduction, hydrolysis, hydration, or dehalogenation). CYP450 enzymes are triggered by cruciferous vegetables like Brussels sprouts, Spanish black radish, raw or frozen broccoli, cauliflower, and fresh daikon radish sprouts.